呼出气一氧化氮检测对儿童咳嗽变异性哮喘诊断价值的系统评价和meta分析

党向阳, 唐雨一, 李卫国, 刘恩梅

Diagnostic value of fractional exhaled nitric oxide in predicting cough variant asthma in children with chronic cough: a systematic review and meta-analysis

DANG Xiangyang, TANG Yuyi, LI Weiguo, LIU Enmei

表1 CVA与其他慢性咳嗽病因患儿的FeNO水平

Tab 1 FeNO levels of the CVA group and other children with chronic cough

Study	Country	Design	Sample size (CVA/nCVA)	Age/year	Cut-off value/ppb	FeNO measurement	Diagnostic criterion for CVA	FeNO test
Study	Country	Design	Sample size (CVA/nCVA)	Age/year	Cut-off value/ppb	FeNO measurement	Diagnostic criterion for CVA	TP/n	FP/n	FN/n	TN/n
JI et al, 2013^[25]	China	Retrospective	42/44	5‒14	22.5	NIOX MINO (Aerocrine, Sweden)	Chinese guideline for diagnosis and treatment of chronic cough in pediatrics (2008 version)^[18]	37	4	7	38
CAO et al, 2015^[26]	China	Prospective	81/127	0‒12	36	Nano Coulomb Nitric Oxide Analyzer (Sunvou Medical Electronics Co., Ltd., China)	Chinese guideline for diagnosis and treatment of chronic cough in pediatrics (2008 version)^[18]	68	4	13	123
ZHU et al, 2015^[27]	China	Prospective	38/46	6‒12	25.5	NIOX MINO (Aerocrine, Sweden)	Chinese guideline for diagnosis and treatment of chronic cough in pediatrics (2008 version)^[18]	47	8	10	71
NIU et al, 2016^[28]	China	Prospective	106/68	6‒14	20.5	Nano Coulomb Nitric Oxide Analyzer (Sunvou Medical Electronics Co., Ltd., China)	Guideline for diagnosis and treatment of chronic cough in Chinese pediatrics (2013 version)^[19]	79	9	27	59
ZHOU et al, 2018^[29]	China	Prospective	53/62	6‒14	25	NIOX MINO (Aerocrine, Sweden)	ACCP evidence-based clinical practice guideline (2006 version)^[20]	45	2	8	60
YILDIZ et al, 2018^[30]	Turkey	Retrospective	27/63	6‒17	24	NIOX MINO (Aerocrine, Sweden)	ACCP evidence-based clinical practice guideline (2006 version)^[20]	21	5	6	58
ZHOU et al, 2018^[31]	China	Retrospective	41/65	6‒13	27.64	NIOX MINO (Aerocrine, Sweden)	Guideline for diagnosis and treatment of chronic cough in Chinese pediatrics (2013 version)^[19]	36	10	5	55
LI et al, 2018^[32]	China	Retrospective	43/65	0‒12	35	NIOX MINO (Aerocrine, Sweden)	Chinese guideline for diagnosis and treatment of chronic cough in pediatrics (2008 version)^[18]	36	2	7	63
ZHU et al, 2019^[33]	China	Prospective	57/79	6‒12	25.5	NIOX MINO (Aerocrine, Sweden)	Guideline for diagnosis and treatment of chronic cough in Chinese pediatrics (2013 version)^[19]	47	8	10	71