miR-185-5p通过抑制巨噬细胞自噬促进胞内分枝杆菌生长

吴淇琦, 汪豪, 林砺, 晏博, 张舒林

miR-185-5p facilitates intracellular Mycobacterium growth via inhibiting macrophage autophagy

WU Qiqi, WANG Hao, LIN Li, YAN Bo, ZHANG Shulin

图2 miR-185-5p对BCG胞内存活的影响 Note：A. The relative expression level of miR-185-5p in THP-1-derived macrophages transfected with miR-185-5p mimic and mimic NC. B. The relative expression level of miR-185-5p in THP-1-derived macrophages transfected with miR-185-5p inhibitor and inhibitor NC. C. The effect of miR-185-5p up-regulation on the survival of BCG in macrophages after 4 h and 48 h of BCG infection. D. Relative quantification of BCG survival in macrophages with miR-185-5p up-regulation. E. The effect of miR-185-5p down-regulation on the survival of BCG in macrophages after 4 h and 48 h of BCG infection. F. Relative quantification of BCG survival in macrophages with miR-185-5p down-regulation. ①P=0.000, ②P=0.002, ③P=0.041.

Fig 2 Effect of miR-185-5p on intracellular BCG survival