RBX1通过STAT1调控葡萄膜黑色素瘤免疫相关基因
RBX1 regulates uveal melanoma immune-related genes via STAT1
Note： A. Differential gene enrichment analysis after siRBX1-1 (left) or siRBX1-2 (right) intervention compared with siNC. B. Differential genes enriched in the interferon-mediated signaling pathway after siRBX1-1 (left) or siRBX1-2 (right) intervention compared with siNC, and the associated differential genes heat map. NES—normalized enrichment score; STAT2—signal transducer and activator of transcription 2; IL10RB—interleukin 10 receptor subunit β; IFNAR1—interferon α and β receptor subunit 1; IRF9—interferon regulatory factor 9; JAK1—Janus kinase 1; IFNGR2—interferon γ receptor 2; TYK2—tyrosine kinase 2; IFNE—interferon ε; IFNK—interferon κ; IFNGR1—interferon γ receptor 1; PIK3R1—phosphoinositide-3-kinase regulatory subunit 1; IFNA1—interferon α1; IFNA10—interferon α10; IFNA13—interferon α13; IFNA14—interferon α14; IFNA16—interferon α16; IFNA17—interferon α17; IFNA2—interferon α2; IFNA21—interferon α21; IFNA4—interferon α4; IFNA5—interferon α5; IFNA6—interferon α6; IFNA7—interferon α7; IFNA8—interferon α8; IFNB1—interferon β1; IFNG—interferon γ; IFNL1—interferon λ1; IFNL2—interferon λ2; IFNL3—interferon λ3; IFNLR1—interferon λ receptor 1; PIK3CA—phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α; IFNW1—interferon ω1; JAK2—Janus kinase 2; IFNAR2—interferon α and β receptor subunit 2; PRKCA—protein kinase Cα.
