RBX1通过STAT1调控葡萄膜黑色素瘤免疫相关基因

周晓雯, 李倩, 张哲, 沈键锋, 范先群

RBX1 regulates uveal melanoma immune-related genes via STAT1

ZHOU Xiaowen, LI Qian, ZHANG Zhe, SHEN Jianfeng, FAN Xianqun

图5 RBX1 对UVM细胞中 STAT1 及相关基因的表达调控作用 Note：A. mRNA expression of STAT1, CXCL9, and CXCL10 in 92.1 cell line after siRBX1 intervention detected by qPCR. B. mRNA expression of STAT1, CXCL9, and CXCL10 in OMM2.3 cell line after siRBX1 intervention detected by qPCR. C. mRNA expression of STAT1, CXCL9, and CXCL10 in MEL290 cell line after siRBX1 intervention detected by qPCR. D. STAT1 and p-STAT1 protein expression levels in 92.1 cell line after siRBX1 intervention detected by Western blotting. ①P=0.029, ②P=0.009, ③P=0.048, ④P=0.045, ⑤P=0.017, ⑥P=0.006, ⑦P=0.028, ⑧P=0.047, ⑨P=0.001, ⑩P=0.000, 11P=0.018, 12P=0.043, 13P=0.019, 14P=0.002, 15P=0.025, 16P=0.012, 17P=0.033.

Fig 5 Regulation of RBX1 on STAT1 and related genes expressions in UVM cell lines