RBX1通过STAT1调控葡萄膜黑色素瘤免疫相关基因

周晓雯, 李倩, 张哲, 沈键锋, 范先群

RBX1 regulates uveal melanoma immune-related genes via STAT1

ZHOU Xiaowen, LI Qian, ZHANG Zhe, SHEN Jianfeng, FAN Xianqun

图6 STAT1抑制剂对 RBX1 敲低后的UVM细胞中 CXCL9 和 CXCL10 mRNA表达的影响 Note： The RBX1 knockdown cell lines of OMM2.3 (A) and MEL290 (B) were treated with 5 nmol/L and 10 nmol/L fludarabine. The samples were collected after 48 h of dosing and qPCR was performed. ①P=0.002, ②P=0.003, ③P=0.041, ④P=0.006, ⑤P=0.004, ⑥P=0.007, ⑦P=0.000, ⑧P=0.027, ⑨P=0.012, ⑩P=0.008, 11P=0.035.

Fig 6 Effect of STAT1 inhibitor on the mRNA expression of CXCL9 and CXCL10 in UVM cell lines after RBX1 knockdown