轻链单个氨基酸改变可增强新冠病毒嵌合抗体的中和能力

殷姿, 廉朝阳, 高波, 田莹, 郝茜, 叶菱秀

Enhancement of the neutralization ability resulting from a single amino acid change in the light chain of a chimeric antibody against SARS-CoV-2

YIN Zi, LIAN Chaoyang, GAO Bo, TIAN Ying, HAO Qian, YEAP Lengsiew

图 2 鼠源抗体轻链基因文库构建及高亲和力人鼠嵌合抗体筛选流程

Fig 2 Construction of mouse-origin antibody light chain gene library and screening workflow of high-affinity human-mouse chimeric antibody