轻链单个氨基酸改变可增强新冠病毒嵌合抗体的中和能力

殷姿, 廉朝阳, 高波, 田莹, 郝茜, 叶菱秀

Enhancement of the neutralization ability resulting from a single amino acid change in the light chain of a chimeric antibody against SARS-CoV-2

YIN Zi, LIAN Chaoyang, GAO Bo, TIAN Ying, HAO Qian, YEAP Lengsiew

图 4 2组小鼠的血清抗体水平及各类B细胞水平分析 Note：A. Detection of serum antibody titer using ELISA with SARS-CoV-2 RBD antigen. B. Detection of serum antibody titer using ELISA with SARS-CoV-2 S-trimer antigen. C. Detection of the proportions of different types of B cells in the spleen and lymph nodes of the two groups by flow cytometry.

Fig 4 Analysis of serum antibody levels and different types of B cell levels in the two groups of mice