轻链单个氨基酸改变可增强新冠病毒嵌合抗体的中和能力

殷姿, 廉朝阳, 高波, 田莹, 郝茜, 叶菱秀

Enhancement of the neutralization ability resulting from a single amino acid change in the light chain of a chimeric antibody against SARS-CoV-2

YIN Zi, LIAN Chaoyang, GAO Bo, TIAN Ying, HAO Qian, YEAP Lengsiew

图 6 高亲和力人鼠嵌合轻链上单个氨基酸位点的改变分析以及单个氨基酸改变的抗体的纯化 Note：A. Display of amino acid sequences of the screened chimeric antibodies and antibodies with single amino acid changes in light chains. B. SDS-PAGE results for chimeric antibodies purification.

Fig 6 Analysis of single amino acid site changes in the light chain of high-affinity human-mouse chimeric antibody and purification of antibodies with single amino acid changes