轻链单个氨基酸改变可增强新冠病毒嵌合抗体的中和能力

殷姿, 廉朝阳, 高波, 田莹, 郝茜, 叶菱秀

Enhancement of the neutralization ability resulting from a single amino acid change in the light chain of a chimeric antibody against SARS-CoV-2

YIN Zi, LIAN Chaoyang, GAO Bo, TIAN Ying, HAO Qian, YEAP Lengsiew

图 7 单个氨基酸改变对高亲和力的人鼠嵌合抗体的亲和力及中和能力的影响 Note： A. Analysis of antibody binding affinity by ELISA. B. Analysis of antibody neutralizing ability by pseudovirus neutralization assay.

Fig 7 Effect of single amino acid changes on the affinity and neutralization ability of high-affinity human-mouse chimeric antibodies