茶褐素生物学活性及其作用机制的研究进展
王洁仪, 郑丹, 郑晓皎, 贾伟, 赵爱华

Research progress in biological activities and mechanisms of theabrownin
WANG Jieyi, ZHENG Dan, ZHENG Xiaojiao, JIA Wei, ZHAO Aihua
表1 茶褐素干预后显著变化的肠道菌群
Tab 1 Significantly differential gut microbiota after theabrownin intervention
Animal modelUp-regulated gut microbiotaDown-regulated gut microbiotaReference
Azoxymethane/dextran sodium sulphate-induced colorectal cancer in mice

Family: Rinoccaceae, Ruminococcaceae, Prevotellaceae

Genus: Romboutsia, Anaeroplasma, Ruminococcus, Parabacteroides, Rikenellaceae RC9, Parvibacter, Alloprevotella

Family: Bacteroidceae

Genus: Bacteroides

[8]
Mice with high-fat dietGenus: Lactobacillus, Bacillus, Streptococcus, Lactococcus, Enterococcus[6]
Rats with high-sugar diet

Phylum: Bacteroidetes, Proteobacteria

Genus: Alloprevotella, Coprostanoligenes group, Bacteroides, Prevotellaceae NK3B31 group, Desulfovibrio, Intestinimonas, Astipes, Bifidobacterium, Phascolarctobacterium, Ruminococcaceae UCG-010, Staphylococcus

Species: Bacteroides acidifaciens, Staphylococcus saprophyticus subsp., Lactobacillus murinus

Phylum: Firmicutes

Family: Prevotellaceae Ga6A1 group

Genus: Lactobacillus, Tyzzerella

[23]
Mice with high-fat dietSpecies: Clostridium scindens, Akmermansia muciniphila, Parabacteroides distasonis[21]
db/db Mice with high-fat dietSpecies: Clostridioides difficile 42_27, Blautia coccoides, Firmicutes bacterium ASF500Species: Brevundimonas vesicularis[24]
Mice with high-fat dietGenus: Clostridium[25]
Rats with high-fat diet

Phylum: Bacteroidetes, Actinobacteria, Proteobacteria

Species: Bacteroides thetaiotaomicron, Parabacteroides distasonis, Bacteroides acidifaciens, Lactobacillus murinus, Parabacteroides goldsteinii, Corynebacterium variabile

Species: Lachnospiraceae bacterium PG-426-CC-1, Brachyspira sp. NSH-25, Desulfovibrio sp. UNSW3caefatS, Bacteroides uniformis[20]
Rats with high-fat diet

Family: Lachnospiraceae

Genus: Lactobacillus, Akkermansia

Family: Ruminococcaceae

Genus: Desulfovibrio

[26]