水凝胶刚度影响髓核细胞表型及其功能的体内外研究

陈泽昊, 吕振东, 张震, 崔文国, 张煜辉

Effect of hydrogel stiffness on nucleus pulposus cell phenotypes in vitro and its repairment of intervertebral disc in vivo

CHEN Zehao, LÜ Zhendong, ZHANG Zhen, CUI Wenguo, ZHANG Yuhui

图7 不同刚度水凝胶基质培养的髓核细胞对退变椎间盘的修复作用 Note： A. MRI imaging. B. MRI signal intensity. C. H-E and safranin O/fast green staining of intervertebral discs. Black arrows showing annulus fibrosus and violet arrows showing proteoglycans. D. Histological scores at 4 weeks postoperatively. ①P=0.003, ②P=0.017, ③P=0.000, ④P=0.050, compared with the control group.

Fig 7 Repair effect of nucleus pulposus cells cultured in hydrogel matrix with different stiffness on intervertebral disc degeneration