脑卒中后脑血管内皮细胞内质网应激抑制Wnt7/β-catenin通路导致血脑屏障损伤的机制研究

董海平, 谢海怡, 马晓晓, 王震虹

Mechanism of blood-brain barrier damage caused by the inhibition of Wnt7/β-catenin pathway induced by endoplasmic reticulum stress in cerebrovascular endothelial cells after stroke

DONG Haiping, XIE Haiyi, MA Xiaoxiao, WANG Zhenhong

图1 小鼠脑卒中对BBB的损伤以及抑制内质网应激对该损伤的缓解 Note： A. EB exudation in the brain of mice. B. Water content of mice brain. C. Adhesion of cerebrovascular endothelial cells and pericytes in mice. Red arrows indicate overlap of CD31 and CD13. ①P=0.000, compared with the Sham group; ②P=0.011, ③P=0.000, compared with the MCAO group.

Fig 1 Injury of BBB after stroke in mice and the alleviating effect of endoplasmic reticulum stress inhibition on the injury