脑卒中后脑血管内皮细胞内质网应激抑制Wnt7/β-catenin通路导致血脑屏障损伤的机制研究

董海平, 谢海怡, 马晓晓, 王震虹

Mechanism of blood-brain barrier damage caused by the inhibition of Wnt7/β-catenin pathway induced by endoplasmic reticulum stress in cerebrovascular endothelial cells after stroke

DONG Haiping, XIE Haiyi, MA Xiaoxiao, WANG Zhenhong

图3 OGD以及4-PBA处理对HBMEC内质网应激的影响 Note： A. Intracellular Ca2+ level in HBMECs. B. Intracellular ROS level in HBMECs. C. Expression of endoplasmic reticulum stress proteins in HBMECs. ①P=0.003, ③P=0.000, compared with the Blank group; ②P=0.033, ④P=0.003, ⑤P=0.000, compared with the OGD group.

Fig 3 Effects of OGD and 4-PBA treatment on HBMEC endoplasmic reticulum stress