CXCL9在乳腺癌中的表达及其与肿瘤免疫浸润特征的相关性研究

杜少倩, 陶梦玉, 曹源, 王红霞, 胡孝渠, 范广建, 臧丽娟

CXCL9 expression in breast cancer and its correlation with the characteristics of tumor immunoinfiltration

DU Shaoqian, TAO Mengyu, CAO Yuan, WANG Hongxia, HU Xiaoqu, FAN Guangjian, ZANG Lijuan

图6 乳腺癌中 CXCL9 mRNA表达与TIIC浸润水平的相关性分析 Note： A. Spearman correlation analysis of TIICs infiltration ratio and CXCL9 mRNA expression. B. Observation of the relationship between CXCL9 expression and CD8+ T cells infiltration ratio by IHC. S—stroma; T—tumor. C. Correlation between CXCL9 expression and the number of CD8+ T cells infiltration by beeswarm plot. D. Fluorescence images of CXCL9+ cell species in breast cancer interstitium. Yellow indicates CXCL9, orange indicates CD68, green indicates CD11c, red indicates CK7, and blue indicates DNA. The left dashed box indicates the field of upper 3 small figures, and the right one indicates the field of lower 3 small figures. The arrows indicate CXCL9+CD68+ cells or CXCL9+CD11c+ cells.

Fig 6 Correlation between CXCL9 mRNA expression and TIICs infiltration ratio in breast cancer