18F-MD-PSMA PET/CT显像在中高危前列腺癌初始分期中的应用价值
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严叶青, 梁胜, 杨斌, 邹仁健, 马玉飞, 蔡利生, 王辉, 傅宏亮
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Role of 18F-MD-PSMA PET/CT in initial stage of intermediate and high risk prostate cancer
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YAN Yeqing, LIANG Sheng, YANG Bin, ZOU Renjian, MA Yufei, CAI Lisheng, WANG Hui, FU Hongliang
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表1 CI与 18F-MD-PSMA PET/CT在PCa初始分期中的诊断效能比较
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Tab 1 Comparison of diagnostic performance between CI and 18F-MD-PSMA PET/CT in initial staging of PCa
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| Organ/region examined | TP/n | FP/n | TN/n | FN/n | SEN/% | SPEC/% | PPV/% | NPV/% | ACU/% |
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| EPE | | | | | | | | | | | mp-MRI | 13 | 1 | 9 | 15 | 46.4 | 90.0 | 92.9 | 37.5 | 57.9 | | 18F-MD-PSMA PET/CT | 25 | 6 | 4 | 3 | 89.3 | 40.0 | 80.6 | 57.1 | 76.3 | | SVI | | | | | | | | | | | mp-MRI | 3 | 2 | 25 | 8 | 27.3 | 92.6 | 60.0 | 75.8 | 73.7 | | 18F-MD-PSMA PET/CT | 8 | 5 | 22 | 3 | 72.7 | 81.4 | 61.5 | 88.0 | 78.9 | | BNI | | | | | | | | | | | mp-MRI | 3 | 1 | 30 | 4 | 42.9 | 96.8 | 75.0 | 88.2 | 86.8 | | 18F-MD-PSMA PET/CT | 3 | 0 | 31 | 4 | 42.9 | 100.0 | 100.0 | 88.6 | 86.8 | | Regional lymph nodes (N1) | | | | | | | | | | | Per-lesion | | | | | | | | | | | mp-MRI | 5 | 6 | 387 | 42 | 10.6 | 98.5 | 45.5 | 90.2 | 89.1 | | 18F-MD-PSMA PET/CT | 25 | 11 | 381 | 22 | 53.2 | 96.9 | 70.3 | 94.5 | 92.5 | | 18F-FDG PET/CT | 12 | 6 | 213 | 32 | 29.2 | 99.5 | 66.7 | 86.7 | 87.6 | | Per-patient | | | | | | | | | | | mp-MRI | 3 | 0 | 17 | 8 | 27.3 | 100.0 | 100.0 | 68.0 | 71.4 | | 18F-MD-PSMA PET/CT | 10 | 1 | 16 | 1 | 90.9 | 94.1 | 90.9 | 94.1 | 92.9 | | 18F-FDG PET/CT | 5 | 3 | 6 | 0 | 62.5 | 96.3 | 66.7 | 100.0 | 78.6 | | Skeleton (M1b) | | | | | | | | | | | Per-patient | | | | | | | | | | | BS | 13 | 2 | 32 | 3 | 81.3 | 94.1 | 86.7 | 91.4 | 90.0 | | 18F-MD-PSMA PET/CT | 15 | 0 | 34 | 1 | 93.8 | 100.0 | 100.0 | 97.1 | 98.0 | | Per-lesion | | | | | | | | | | | BS | 11 | 8 | 366 | 34 | 25.0 | 97.9 | 57.9 | 91.5 | 90.0 | | 18F-MD-PSMA PET/CT (per lesion) | 24 | 18 | 356 | 21 | 54.5 | 95.2 | 57.1 | 94.4 | 90.7 |
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