表观遗传修饰调控肺炎免疫应答的研究进展

王青, 韩晓, 张晓波

Research progress of immune response regulated by epigenetic modification in pneumonia

WANG Qing, HAN Xiao, ZHANG Xiaobo

图1 表观遗传修饰调控的免疫失衡对肺炎进展的影响机制 Note： DNMT—DNA methyltransferase; TET—ten eleven translocation; KMT—histone lysine methyltransferase; HAT—histone acetyltransferase; LSD1—lysine specific demethylase 1; HDACs—histone deacetylases; mRNA—messger RNA; miRNA—microRNA; lncRNA—long noncoding RNA; circRNA—circular RNA; METTL3—methyltransferase-like protein 3; WTAP—Wilms′ tumor 1-associating protein; FTO—fat mass and obesity-associated protein; ALKBH5—AlkB homologue 5; YTHDC—YTH domain containing protein.

Fig 1 Mechanisms of immune imbalance regulated by epigenetic modifications on the progression of pneumonia