SIRT2通过组蛋白H4K8去乳酸化修饰调控巨噬细胞趋化功能
SIRT2 regulates macrophage chemotaxis by de-modifying histone H4K8 lactylation
Note： A. Genomic distribution of H4k8la signal peaks. B. Volcano plot of differential genes after LPS stimulation. MERTK—MER proto-oncogene, tyrosine kinase; APBB1IP—amyloid beta precursor protein binding family B member 1 interacting protein; SLC7A8—solute carrier family 7 member 8; LRP1—LDL receptor related protein 1; ADAMTS8—ADAM metallopeptidase with thrombospondin type 1 motif 8; RAB7B—RAB7B, member RAS oncogene family; MSR1—macrophage scavenger receptor 1; SPNS2—SPNS lysolipid transporter 2, sphingosine-1-phosphate; CHST13—carbohydrate sulfotransferase 13; PRAG1—PEAK1 related, kinase-activating pseudokinase 1; SHANK3—SH3 and multiple ankyrin repeat domains 3; DHRS3—dehydrogenase/reductase 3; SPP1—secreted phosphoprotein 1; LGI2—leucine rich repeat LGI family member 2; LOXL4—lysyl oxidase like 4; TAC4—tachykinin precursor 4; P2RY12—purinergic receptor P2Y12; TRAF1—TNF receptor associated factor 1; CACNA1E—calcium voltage-gated channel subunit alpha1 E; PARM1—prostate androgen-regulated mucin-like protein 1; EBI3—Epstein-Barr virus induced 3; ABTB2—ankyrin repeat and BTB domain containing 2; CCL5—C-C motif chemokine ligand 5; PERP—p53 apoptosis effector related to PMP22; IL1B—interleukin 1 beta; CKB—creatine kinase B; RFTN1—raftlin, lipid raft linker 1; TNFAIP2—TNF alpha induced protein 2; MT2A—metallothionein 2A; ECE1—endothelin converting enzyme 1; CHST2—carbohydrate sulfotransferase 2; GIMAP8—GTPase, IMAP family member 8; TNF—tumor necrosis factor; SLAMF7—SLAM family member 7; NRP2—neuropilin 2; SERPINE2—serpin family E member 2; KCNQ4—potassium voltage-gated channel subfamily Q member 4; ADA—adenosine deaminase; SOCS3—suppressor of cytokine signaling 3; DLL4—delta like canonical Notch ligand 4; HIVEP2—HIVEP zinc finger 2; TFPI2—tissue factor pathway inhibitor 2; PIM2—Pim-2 proto-oncogene, serine/threonine kinase; KCNN2—potassium calcium-activated channel subfamily N member 2; DTX4—deltex E3 ubiquitin ligase 4; TFPI2—tissue factor pathway inhibitor 2; PTGS2—prostaglandin-endoperoxide synthase 2; MCOLN2—mucolipin TRP cation channel 2; EVA1A—eva-1 homolog A, regulator of programmed cell death; RIN3—Ras and Rab interactor 3; SLC7A2—solute carrier family 7 member 2; TNFAIP6—TNF alpha induced protein 6; IGFBP5—insulin like growth factor binding protein 5; SERPINB7—serpin family B member 7; IDO1—indoleamine 2,3-dioxygenase 1; SERPINA9—serpin family A member 9; CCL1—C-C motif chemokine ligand 1; CCR7—C-C motif chemokine receptor 7; CSF2—colony stimulating factor 2; LAMP3—lysosomal associated membrane protein 3.
