SIRT2通过组蛋白H4K8去乳酸化修饰调控巨噬细胞趋化功能

宋文汀, 陶悦, 潘艺, 莫茜, 曹清

SIRT2 regulates macrophage chemotaxis by de-modifying histone H4K8 lactylation

SONG Wenting, TAO Yue, PAN Yi, MO Xi, CAO Qing

图6 RNA-seq及ChIP-seq交互分析 Note： A. Gene set enrichment analysis of macrophages after LPS stimulation. NES—normalized enrichment score. B. Heatmap for macrophage chemotaxis- related genes bound to H4K8la. CTRL1, CTRL2, and CTRL3 were three replicate samples from the control group, while LPS1, LPS2, and LPS3 were three replicate samples from the LPS-treated infection group. PIK3CB—phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; DPYSL3—dihydropyrimidinase like 3; JAG1—jagged canonical Notch ligand 1; FMNL3—formin like 3; CXCL1—C-X-C motif chemokine ligand 1; PRKCD—protein kinase C delta; SMAD3—SMAD family member 3; PTAFR—platelet activating factor receptor; CDH2—cadherin 2.

Fig 6 Interaction analysis of RNA-seq and ChIP-seq