PRPS1 I72位点突变对急性淋巴细胞白血病耐药性的影响及其机制研究

崔芷嫣, 陈尧, 陶悦, 沈树红, 李慧

Effects of PRPS1 I72 mutations on drug resistance in acute lymphoblastic leukemia and its mechanisms

CUI Zhiyan, CHEN Yao, TAO Yue, SHEN Shuhong, LI Hui

图4 PRPS1 I72位点突变对经6-MP诱导的REH细胞的DNA损伤和细胞凋亡的影响 Note： A/B. Flow scatter plots (A) and statistical analysis (B) of the detection of apoptosis rates for each REH cell line by Annexin Ⅴ/DAPI double staining. ①P=0.000, compared with REH cells transfected with pGV303 PRPS1 WT plasmid; ②P=0.000, compared with REH cells transfected with pGV303 PRPS1 I72V plasmid. C. Detection of the protein expression of DNA damage biomarkers and apoptosis-related proteins by Western blotting.

Fig 4 Effect of mutations at PRPS1 I72 locus on the apoptosis and DNA damage in REH cells induced by 6-MP