PRPS1 I72位点突变对急性淋巴细胞白血病耐药性的影响及其机制研究

崔芷嫣, 陈尧, 陶悦, 沈树红, 李慧

Effects of PRPS1 I72 mutations on drug resistance in acute lymphoblastic leukemia and its mechanisms

CUI Zhiyan, CHEN Yao, TAO Yue, SHEN Shuhong, LI Hui

表1 ALL患者中未验证功能变化的 PRPS1 突变的信息

Tab 1 Information of PRPS1 mutations with unverified functional changes in patients with ALL

Sample ID Gender Immuno-phenotype Allele change Amino acid change Relapse time/d Time of relapse① Subtype CCCG2018 M B-ALL A>T I72F 638 early relapse BCR_ABL1 ALL208 M B-ALL A>C R177S 341 early relapse PAX5_MPRIP ALL086 M B-ALL G>C V316L 427 early relapse ETV6_RUNX1