转位分子蛋白经由Keap1/Nrf2/HO-1通路激活自噬缓解大鼠糖尿病神经病理性疼痛

高楠, 郝璨, 马冰洁, 靳天, 马柯, 刘晓明

Translocator protein activates autophagy in diabetic neuropathic pain rats via regulation of the Keap1/Nrf2/HO-1 signaling

GAO Nan, HAO Gem, MA Bingjie, JIN Tian, MA Ke, LIU Xiaoming

图4 鞘内注射TSPO激动剂Ro5-4864改善DNP大鼠坐骨神经中自噬相关蛋白表达的变化 (n=3) Note：A. Representative immunoblots of p62, Beclin-1 and LC3-II in the sciatic nerves of the rats. B?D. Illustration of the relative expression of p62 (B), Beclin-1 (C), and LC3-Ⅱ (D). ①P=0.000, compared with the Sham group; ②P=0.001, ③P=0.000, compared with the DNP group.

Fig 4 TSPO agonist Ro5-4864 improved the changes in the expression of autophagy-related proteins in the sciatic nerves of DNP rats (n=3)