转位分子蛋白经由Keap1/Nrf2/HO-1通路激活自噬缓解大鼠糖尿病神经病理性疼痛

高楠, 郝璨, 马冰洁, 靳天, 马柯, 刘晓明

Translocator protein activates autophagy in diabetic neuropathic pain rats via regulation of the Keap1/Nrf2/HO-1 signaling

GAO Nan, HAO Gem, MA Bingjie, JIN Tian, MA Ke, LIU Xiaoming

图5 鞘内注射TSPO激动剂Ro5-4864改善DNP大鼠坐骨神经Nrf2表达的降低 (n=3) Note：A. Representative immunofluorescent pictures of single staining of Nrf2 in the sciatic nerves of the rats. B. Quantitative analysis of Nrf2 signal intensity. ①P=0.000, compared with the Sham group; ②P=0.000 compared with the DNP group.

Fig 5 TSPO agonist Ro5-4864 blocked the decrease in the expression of Nrf2 in the sciatic nerves of DNP rats (n=3)