转位分子蛋白经由Keap1/Nrf2/HO-1通路激活自噬缓解大鼠糖尿病神经病理性疼痛

高楠, 郝璨, 马冰洁, 靳天, 马柯, 刘晓明

Translocator protein activates autophagy in diabetic neuropathic pain rats via regulation of the Keap1/Nrf2/HO-1 signaling

GAO Nan, HAO Gem, MA Bingjie, JIN Tian, MA Ke, LIU Xiaoming

图6 鞘内注射TSPO激动剂Ro5-4864对DNP大鼠坐骨神经中Keap1/Nrf2/HO-1通路相关蛋白表达的影响 (n=3) Note：A/B. Representative immunoblots of nuclear Nrf2 (A) and HO-1 (B). C/D. Illustration of the relative expression of nuclear Nrf2 (C) and HO-1 (D). ①P=0.000, compared with the Sham group; ②P=0.000, compared with the DNP group.

Fig 6 Effects of TSPO agonist Ro5-4864 on the expression of Keap1/Nrf2/HO-1 signaling-related proteins in the sciatic nerves of DNP rats (n=3)