转位分子蛋白经由Keap1/Nrf2/HO-1通路激活自噬缓解大鼠糖尿病神经病理性疼痛

高楠, 郝璨, 马冰洁, 靳天, 马柯, 刘晓明

Translocator protein activates autophagy in diabetic neuropathic pain rats via regulation of the Keap1/Nrf2/HO-1 signaling

GAO Nan, HAO Gem, MA Bingjie, JIN Tian, MA Ke, LIU Xiaoming

图7 Nrf2抑制剂ML385对TSPO激动剂Ro5-4864作用的影响 Note：A. Effects of Nrf2 inhibitor ML385 on the 50% PMWT of the rats (n=6). B. Representative immunoblots of nuclear Nrf2 and HO-1 in the sciatic nerves (n=3). C. Representative immunoblots of p62, Beclin-1 and LC3-Ⅱ (n=3). D/E. Illustration of the relative expression of nuclear Nrf2 (D) and HO-1 (E). F?H. Illustration of the relative expression of p62 (F), Beclin-1 (G), LC3-Ⅱ (H). ①P=0.000, ②P=0.006, ③P=0.003, compared with the Ro group.

Fig 7 Effects of Nrf2 inhibitor ML385 on the changes induced by TSPO agonist Ro5-4864 in DNP rats