大黄对大鼠体内肠道菌群-宿主共代谢作用的影响
高羽, 殷姗, 庞玥, 梁文懿, 刘玉敏

Effect of rhubarb on gut microbiota-host co-metabolism in rats
GAO Yu, YIN Shan, PANG Yue, LIANG Wenyi, LIU Yumin
表1 对照组和实验组大鼠体内的差异性代谢物
Tab 1 Significant metabolites in rats of the control group and the rhubarb administration groups
ClassSignificant metaboliteRelated bacteria [7, 15-17]Fc
SerumColonFecal
Fc1Fc2Fc3Fc1Fc2Fc3Fc1Fc2Fc3
Metabolites of gut microbial-proteins, peptides and amino acids/gut microbial-host co-metabolismCatechol

Lactobacillus[+ -]

Clostridium[]

1.09-1.061.42
Phenylpropionic acid1.011.751.485.278.355.44
2-hydroxyphenylpropionic acid-2.08-2.33-2.33
L-DOPA1.10-1.44-1.30
Phenylalanine1.121.201.23-1.28-1.43-1.49
Tyrosine1.411.531.58
4-aminobutyric acidClostridium[]-1.30-1.79-1.35
Ornithine1.211.312.03-2.08-1.85-2.00
Spermidine1.582.172.30
Tryptophan

Escherichia coli[+ -]

Bifidobacterium[+]

1.071.411.46
Indole-3-acetic acid1.122.061.92
Indole-3-propionic acid1.00-1.10-2.00
Indole-3-lactic acid1.081.361.43
Kynurenic acid1.291.44-7.14
Xanthuric acid-1.09-1.25-1.47
Nicotinic acid-1.11-1.112.85-1.12-1.25-1.28
Deoxycholic acid

Lactobacillus[+ -]

Bifidobacterium[+]

Bacteroides[+]

Escherichia coli[+ -]

Clostridium[]

-1.031.042.88
Cholesterol1.751.842.46-1.85-4.17-3.85
Isoleucine1.181.181.22-1.26-1.28-1.39
Leucine1.151.191.24-1.17-1.25-1.26
Valine1.211.191.26-1.21-1.58-1.67
Isovaleric acid1.281.02-2.94
Caproic acid1.044.374.30
TCA cycleFumaric acid

Bifidobacterium[+]

Lactobacillus[+ -]

2.292.843.831.731.281.25-1.85-1.79-1.75
Malic acid1.602.283.491.71-1.061.00-1.64-2.17-2.04
α-ketoglutaric acid1.331.341.60
Citric acid1.481.411.74
Isocitrate1.531.641.77
TCA cycle-amino acidGlutamic acid1.271.311.43-1.23-1.61-1.72
Glutamine2.152.373.08
Aspartic acid1.311.461.60
Asparagine1.171.591.40
TCA cycle-glycometabolismPyruvate

Bifidobacterium[+]

Bacteroides[+]

Lactobacillus[+ -]

1.091.371.67-1.031.472.48
Lactic acid1.161.461.461.55-1.07-1.05-3.52-2.68-1.05
Fructose1.081.231.411.462.203.41
6-phosphogluconic acid-1.09-1.10-1.331.341.55-10.00
D-glycero-1-phosphate1.451.952.03-1.35-1.37-1.69
Glucose-1-phosphate1.050.851.421.311.22-2.63-1.25-1.29-1.31
β-glycerophosphate-1.331.00-1.56
Ethanolamine phosphate1.21-1.67-1.96
Phosphoenolpyruvate1.541.32-1.56
TCA cycle-lipid metabolismLinolenic acid

Bifidobacterium[+]

Lactobacillus[+-]

1.04-1.53-1.52
Docosanoic acid1.323.291.92
13-docosenoic acid1.431.802.27
1-monostearoylglycerol-1.301.011.53