BRCA1 R1325K突变对胆囊癌细胞增殖及凋亡的影响

杨婧潇, 贾子尧, 吴文广, 吴向嵩, 张飞, 李怀峰, 朱逸荻, 李茂岚

Effect of BRCA1 R1325K mutation on proliferation and apoptosis of gallbladder cancer cells

YANG Jingxiao, JIA Ziyao, WU Wenguang, WU Xiangsong, ZHANG Fei, LI Huaifeng, ZHU Yidi, LI Maolan

图1 BRCA1 野生型及 BRCA1 R1325K突变过表达慢病毒感染后胆囊癌细胞系GBC-SD和NOZ中BRCA1蛋白的表达情况 Note： A. Western blotting was used to detect BRCA1 protein expression in GBC-SD cell line. B. Western blotting was used to detect BRCA1 protein expression in NOZ cell line. ①P=0.000, ②P=0.003, ③P=0.001.

Fig 1 Expression of BRCA1 protein in gallbladder cancer cell lines GBC-SD and NOZ after BRCA1 wild-type and BRCA1 R1325K mutation overexpression lentivirus infection