缺氧诱导因子-1α抑 制剂YC-1改善糖尿病肾病小鼠肾脏损伤的机制研究

贾君杰, 邢海帆, 张群子, 刘奇烨, 汪年松, 范瑛

Renal protective effect and mechanism research of hypoxia inducible factor-1α inhibitor YC-1 in diabetic nephropathy mice

JIA Junjie, XING Haifan, ZHANG Qunzi, LIU Qiye, WANG Niansong, FAN Ying

图1 YC-1对db/db小鼠肾脏组织病理损伤的影响 Note： A. Renal histology evaluations of different groups were performed with H-E staining and PAS staining (×200, scale bar=50 μm). B. Mesangial matrix index expressed as the ratio of mesangial matrix area to glomerular tuft area. C. Analysis of tubular injury score. ①P=0.000, compared with WT group; ②P=0.000, compared with DB group.

Fig 1 Effect of YC-1 on kidney histopathology injuries in the db/db mice