缺氧诱导因子-1α抑 制剂YC-1改善糖尿病肾病小鼠肾脏损伤的机制研究

贾君杰, 邢海帆, 张群子, 刘奇烨, 汪年松, 范瑛

Renal protective effect and mechanism research of hypoxia inducible factor-1α inhibitor YC-1 in diabetic nephropathy mice

JIA Junjie, XING Haifan, ZHANG Qunzi, LIU Qiye, WANG Niansong, FAN Ying

图2 YC-1对db/db小鼠肾脏纤维化的影响 Note： A. Extracellular matrix accumulation and collagen fiber deposition were determined with Masson trichrome staining and immunohistochemical staining of collagen-Ⅰ (×200, scale bar=50 μm). B. Western blotting analysis and quantification of the expression of the pro?brotic molecule α-SMA. ①P=0.000, compared with the WT group; ②P=0.009, compared with the DB group.

Fig 2 Effect of YC-1 on kidney fibrosis in the db/db mice