缺氧诱导因子-1α抑 制剂YC-1改善糖尿病肾病小鼠肾脏损伤的机制研究

贾君杰, 邢海帆, 张群子, 刘奇烨, 汪年松, 范瑛

Renal protective effect and mechanism research of hypoxia inducible factor-1α inhibitor YC-1 in diabetic nephropathy mice

JIA Junjie, XING Haifan, ZHANG Qunzi, LIU Qiye, WANG Niansong, FAN Ying

图3 YC-1对db/db小鼠肾脏HIF-1α表达的影响 Note： A. Immunohistochemical staining of HIF-1α in kidney tissues (×200, scale bar=50 μm). B. Western blotting analysis and quantification of HIF-1α expression. ①P=0.000, compared with the WT group; ②P=0.000, compared with the DB group.

Fig 3 Effect of YC-1 on HIF-1α expression in the kidneys of db/db mice