缺氧诱导因子-1α抑 制剂YC-1改善糖尿病肾病小鼠肾脏损伤的机制研究

贾君杰, 邢海帆, 张群子, 刘奇烨, 汪年松, 范瑛

Renal protective effect and mechanism research of hypoxia inducible factor-1α inhibitor YC-1 in diabetic nephropathy mice

JIA Junjie, XING Haifan, ZHANG Qunzi, LIU Qiye, WANG Niansong, FAN Ying

图4 YC-1对db/db小鼠肾脏细胞凋亡的影响 Note： A. Representative TUNEL staining photographs (×200, scale bar=50 μm) and quantification analysis of TUNEL positive cells under each high power field. The data are presented as boxplot. B. Western blotting analysis and quantification of the expression of BAX, BCL-2, and cleaved caspase-3. ①P=0.000, ④P=0.004, compared with the WT group; ②P=0.011, ③P=0.000, ⑤P=0.021, compared with the DB group.

Fig 4 Effect of YC-1 on cell apoptosis in the kidneys of the db/db mice