缺氧诱导因子-1α抑 制剂YC-1改善糖尿病肾病小鼠肾脏损伤的机制研究

贾君杰, 邢海帆, 张群子, 刘奇烨, 汪年松, 范瑛

Renal protective effect and mechanism research of hypoxia inducible factor-1α inhibitor YC-1 in diabetic nephropathy mice

JIA Junjie, XING Haifan, ZHANG Qunzi, LIU Qiye, WANG Niansong, FAN Ying

图5 YC-1对db/db小鼠肾脏ERS的影响 Note： A. Representative Western blotting bands. t-PERK—total-PERK; t-eIF2α—total-eIF2α. B. Quantification of Western blotting bands. ①P=0.000, ⑤P=0.035, compared with the WT group; ②P=0.011, ③P=0.000, ④P=0.002, ⑥P=0.048, compared with the DB group.

Fig 5 Effect of YC-1 on ERS in the kidneys of db/db mice