缺氧诱导因子-1α抑 制剂YC-1改善糖尿病肾病小鼠肾脏损伤的机制研究

贾君杰, 邢海帆, 张群子, 刘奇烨, 汪年松, 范瑛

Renal protective effect and mechanism research of hypoxia inducible factor-1α inhibitor YC-1 in diabetic nephropathy mice

JIA Junjie, XING Haifan, ZHANG Qunzi, LIU Qiye, WANG Niansong, FAN Ying

表1 YC-1对WT和db/db小鼠一般情况和肾功能指标的影响（n=6）

Tab 1 Effect of YC-1 on general physical signs and kidney function indexes in the WT and db/db mice （n=6）

Index WT group WT+YC-1 group DB group DB+YC-1 group RBG/(mmol·L-1) 8.10±0.39 8.25±0.43 28.57±1.18① 29.15±1.29① BW/g 27.47±0.58 25.98±0.65 56.72±1.05① 54.53±1.02① KW/BW/(mg·g-1) 9.97±0.23 10.19±0.23 12.25±0.22① 11.31±0.14①② Scr/(mg·dL-1) 0.239±0.010 0.263±0.012 0.473±0.017① 0.414±0.016①③ UACR/(μg·mg-1) 61.68±12.18 67.46±10.71 1 445.61±63.10① 663.94±60.19①② uNGAL/(μg·mL-1) 23.70±1.09 23.04±0.95 118.66±2.98① 86.02±3.44①②