七氟烷抑制新生小鼠前额叶皮质神经祖细胞向神经元分化发育

刘思雨, 张磊

Sevoflurane inhibits the differentiation and development of neural progenitor cells into neurons in the prefrontal cortex of newborn mice

LIU Siyu, ZHANG Lei

图9 新生小鼠七氟烷麻醉后PFC神经元的转录组变化和功能注释分析 Note：A. Volcano map showing differentially expressed genes between Sev1 group and Ctrl group. B/C. Top 15 enrichment entries of down-regulated genes (B) and up-regulated genes (C) in the GO-BP database between Sev1 group and Ctrl group. D. Volcano map showing differentially expressed genes between Sev3 group and Ctrl group. E/F. Top 15 enrichment entries of down-regulated genes (E) and up-regulated genes (F) in the GO-BP database between Sev3 group and Ctrl group. Entries highlighted in red represent biological processes associated with PFC neurogenesis.

Fig 9 Analysis of transcriptome changes and functional annotation of PFC neurons in neonatal mice after sevoflurane anesthesia