前列腺癌患者内分泌治疗相关不良反应的潜在剖面分析
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朱涵菁, 殷弘凡, 尤思洁, 杨艳
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Latent profile analysis of adverse effects associated with endocrine therapy in prostate cancer patients based on the theory of unpleasant symptoms
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ZHU Hanjing, YIN Hongfan, YOU Sijie, YANG Yan
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表1 患者的一般资料及不同PCa内分泌治疗相关不良反应潜在类别的特征分析（N=274）
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Tab 1 General information of patients with endocrine therapy in prostate cancer and characterization of potential categories of adverse reactions associated with different endocrine therapies for prostate cancer （N=274）
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| Item | Category of potential profile | χ2/F | P value |
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Mild symptom (n=96) | Moderate symptom (n=111) | Severe symptom (n=67) |
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| Age/n (%) | | | | 10.475 | 0.033 | | ≤65 year | 29 (30.2) | 32 (28.8) | 22 (32.8) | | | | >65 year and≤75 year | 39 (40.6) | 63 (56.8) | 36 (53.7) | | | | >75 year | 28 (29.2) | 16 (14.4) | 9 (13.6) | | | Annual treatment cost as a percentage of monthly per capita household income/n (%) | | | | 10.175 | 0.038 | | ≤30% | 51 (53.1) | 65 (58.6) | 27 (40.3) | | | | >30% and ≤60% | 24 (25.0) | 25 (22.5) | 14 (20.9) | | | | >60% | 21 (21.9) | 21 (18.9) | 26 (38.8) | | | | T stage/n (%) | | | | 12.175 | 0.016 | | T2 | 22 (22.9) | 32 (28.8) | 6 (8.9) | | | | T3 | 45 (46.8) | 38 (34.2) | 32 (47.8) | | | | T4 | 29 (30.3) | 41 (37.0) | 29 (43.3) | | | | N stage/n (%) | | | | 9.104 | 0.011 | | N0 | 56 (58.3) | 54 (48.6) | 23 (34.3) | | | | N1 | 40 (41.7) | 57 (51.4) | 44 (65.7) | | | | M stage/n (%) | | | | 13.923 | 0.001 | | M0 | 58 (60.4) | 59 (53.2) | 21 (31.3) | | | | M1 | 38 (39.6) | 52 (46.8) | 46 (68.7) | | | | PSA value/n (%) | | | | 30.292 | 0.000 | | ≤0.01 ng·mL-1 | 34 (35.4) | 37 (33.3) | 21 (31.3) | | | | >0.01 ng·mL-1 and ≤ 0.2 ng·mL-1 | 30 (31.2) | 41 (36.9) | 7 (10.4) | | | | >0.2 ng·mL-1 and ≤ 2 ng·mL-1 | 19 (19.8) | 11 (9.9) | 10 (14.9) | | | | >2 ng·mL-1 | 13 (13.6) | 22 (19.9) | 29 (43.4) | | | | Gene detection/n (%) | | | | 9.719 | 0.045 | | Not done | 45 (46.9) | 59 (53.2) | 30 (44.8) | | | | Not mutated | 26 (27.1) | 14 (12.6) | 10 (14.9) | | | | Mutated | 25 (26.0) | 38 (34.2) | 27 (40.3) | | | | Psychosocial adjustment score/score | 49.94±27.046 | 64.5±12.803 | 65.93±14.506 | 50.100 | 0.000 | | Perceived social support score/score | 59.86±21.848 | 51.00±22.623 | 46.67±24.319 | 14.233 | 0.001 | | Uncertainty in illness score/score | 88.16±31.145 | 99.67±22.576 | 110.49±21.970 | 47.881 | 0.000 |
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