前列腺癌患者内分泌治疗相关不良反应的潜在剖面分析

朱涵菁, 殷弘凡, 尤思洁, 杨艳

Latent profile analysis of adverse effects associated with endocrine therapy in prostate cancer patients based on the theory of unpleasant symptoms

ZHU Hanjing, YIN Hongfan, YOU Sijie, YANG Yan

表5 潜在类别影响因素的多元Logistic回归

Tab 5 Multi-variable logistic regression analysis of potential categorical influencing factors

Item Moderate symptom Severe symptom β SE Wald P value OR (95%CI) β SE Wald P value OR (95%CI) Constant -3.597 1.248 8.302 0.004 - -2.660 1.341 3.937 0.047 Psychosocial adjustment score 0.038 0.010 13.279 0.000 1.038 (1.018‒1.060) 0.026 0.012 5.065 0.024 1.027 (1.003‒1.051) Perceived social support score -0.002 0.008 0.047 0.827 0.998 (0.983‒1.014) -0.008 0.009 0.773 0.379 0.992 (0.975‒1.010) Uncertainty in illncss score 0.009 0.008 1.400 0.237 1.009 (0.994‒1.024) 0.021 0.008 6.532 0.011 1.021 (1.005‒1.038) M Stage M0 -0.588 0.425 1.912 0.167 0.555 (0.241‒1.278) -1.037 0.489 4.499 0.034 0.354 (0.136‒0.924) M1 0 - - - - 0 - - - - PSA value ≤0.01 ng·mL-1 -0.062 0.520 0.014 0.905 0.940 (0.339‒2.605) -0.770 0.528 2.128 0.145 0.463 (0.164‒1.303) >0.01 ng·mL-1 and ≤0.2 ng·mL-1 -0.126 0.525 0.057 0.811 0.882 (0.315‒2.467) -1.953 0.622 9.859 0.002 0.142 (0.042‒0.480) >0.2 ng·mL-1 and ≤ 2 ng·mL-1 -1.238 0.611 4.110 0.043 0.290 (0.088‒0.960) -1.292 0.613 4.442 0.035 0.275 (0.083‒0.914) >2 ng·mL-1 0 - - - - 0 - - - - Gene detection Not done -1.090 0.490 4.945 0.026 0.336 (0.129‒0.879) -0.569 0.575 0.980 0.322 0.566 (0.183‒1.746) Not mutated -0.555 0.407 1.859 0.173 0.574 (0.259‒1.275) -0.323 0.470 0.473 0.492 0.724 (0.288‒1.819) Mutated 0 - - - - 0 - - - -