食管鳞癌内镜黏膜下剥离术后T1b患者再治疗策略分析
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朱开元, 苏瑜琛, 刘智超, 章宏, 李春光, 张杰, 李志刚
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Adjuvant strategies for patients with T1b invasion after endoscopic submucosal dissection for esophageal squamous cell carcinoma
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ZHU Kaiyuan, SU Yuchen, LIU Zhichao, ZHANG Hong, LI Chunguang, ZHANG Jie, LI Zhigang
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表1 3组患者基线特征比较
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Tab 1 Comparison of baseline characteristics among the 3 groups of patients
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| Characteristic | Total | S group | CRT group | O group | P value |
|---|
| (n=67) | (n=23) | (n=19) | (n=25) |
|---|
| Age/years | 65.3±7.4 | 63.1±4.9 | 64.4±5.5 | 68.1±9.5 | 0.080 | | Gender/n(%) | | | | | 0.078 | | Male | 54 (80.6) | 22 (95.7) | 14 (73.7) | 18 (72.0) | | | Female | 13 (19.4) | 1 (4.3) | 5 (26.3) | 7 (28.0) | | | Smoking history/n(%) | | | | 0.213 | | None | 22 (32.8) | 5 (21.7) | 6 (31.6) | 11 (44.0) | | | Yes | 39 (58.2) | 17 (73.9) | 10 (52.6) | 12 (48.0) | | | Unknown① | 6 (9.0) | 1 (4.3) | 3 (15.8) | 2 (8.0) | | | Alcohol history/n(%) | | | | | 0.834 | | None | 28 (41.8) | 9 (39.1) | 8 (42.1) | 11 (44.0) | | | Yes | 33 (49.2) | 13 (56.5) | 8 (42.1) | 12 (48.0) | | | Unknown① | 6 (9.0) | 1 (4.3) | 3 (15.8) | 2 (8.0) | | | Tumor length/cm | 3.7±2.1 | 4.2±2.6 | 3.1±1.1 | 3.7±2.1 | 0.485 | | Tumor location/n(%) | | | | | 0.655 | | Upper | 6 (9.0) | 2 (8.7) | 3 (15.8) | 1 (4.0) | | | Middle | 26 (38.8) | 9 (39.1) | 8 (42.1) | 9 (36.0) | | | Lower | 35 (52.2) | 12 (52.2) | 8 (42.1) | 15 (60.0) | | | Lesion circumferential ratio/n(%) | | | 0.310 | | <0.50 | 20 (29.9) | 5 (21.7) | 8 (42.1) | 7 (28.0) | | | ≥0.50 and<0.75 | 31 (46.3) | 13 (56.5) | 9 (47.4) | 9 (36.0) | | | ≥0.75 | 12 (17.9) | 5 (21.7) | 1 (5.3) | 6 (24.0) | | | Unknown① | 4 (6.0) | 0 (0) | 1 (5.3) | 3 (12.0) | | | Histological grading/n(%) | | | | 0.084 | | G1 | 14 (20.9) | 5 (21.7) | 4 (21.1) | 5 (20.0) | | | G2 | 29 (43.3) | 5 (21.7) | 9 (47.4) | 15 (60.0) | | | G3 | 14 (20.9) | 9 (39.1) | 2 (10.5) | 3 (12.0) | | | Gx | 10 (14.9) | 4 (17.4) | 4 (21.1) | 2 (8.0) | | | Pathology T stage after ESD/n(%) | | | 0.066 | | pT1b-SM1 | 28 (41.8) | 7 (30.4) | 6 (31.6) | 15 (60.0) | | | pT1b-SM2 | 39 (58.2) | 16 (69.6) | 13 (68.4) | 10 (40.0) | | | Vertical margin/n(%) | | | | | 0.075 | | Positive | 18 (26.9) | 9 (39.1) | 6 (31.6) | 3 (12) | | | Negative | 48 (71.6) | 13 (56.5) | 13 (68.4) | 22 (88) | | | Unknown① | 1 (1.5) | 1 (4.3) | 0 (0) | 0 (0) | | | Horizontal margin/n(%) | | | | 0.814 | | Positive | 21 (31.3) | 6 (26.1) | 6 (31.6) | 9 (36.0) | | | Negative | 45 (67.2) | 16 (69.6) | 13 (68.4) | 16 (64.0) | | | Unknown① | 1 (1.5) | 1 (4.3) | 0 (0) | 0 (0) | | | Lymphovascular invasion/n(%) | | | | 0.279 | | Positive | 7 (10.4) | 4 (17.4) | 2 (10.5) | 1 (4.0) | | | Negative | 57 (85.1) | 17 (73.9) | 17 (89.5) | 23 (92.0) | | | Unknown① | 3 (4.5) | 2 (8.7) | 0 (0) | 1 (4.0) | |
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