m6A甲基化修饰调控肿瘤免疫的研究进展

周海霞, 张靖

Research progress of m6A methylation modification in regulating tumor immunity

ZHOU Haixia, ZHANG Jing

表1 m6A修饰对固有免疫细胞的调控作用

Tab 1 Role of m6A modifications in innate immune cells

Immune cell m6A regulator Type Related factor Function Reference DC METTL3 Writer CD40, CD80 and Tirap Positively correlates with DC maturation and function in promoting T-cell activation [11] YTHDF1 Reader Lysosomal proteases Negatively correlates with cross-presentation of engulfed tumour neoantigens [13] YTHDF2 Reader lnc-Dpf3 Positively correlates with DC migration [12] NK METTL3 Writer SHP-2 Positively correlates antitumor immunity of NK cells [15] YTHDF2 Reader Tardb Positively correlates with NK cell antitumor activity as well as NK cell homeostasis and maturation [16] TAM METTL3 Writer STAT1, STAT3 Positively correlates with M1 macrophage polarization [20-21] YTHDF2 Reader STAT1 Negatively correlates with macrophage reprogramming and antitumor immunity [22] Monocyte METTL3 Writer PGC-1α Positively correlates with monocyte differentiation into different types of macrophages [25] Neutrophil WTAP Writer ENO1 Positively correlates with tumor glycolysis mediated by C5aR1-positive neutrophils [27] FTO Eraser ZEB1 Positively correlates with senescent neutrophils-mediated chemoresistance in breast cancer [28] MDSC METTL3 Writer BHLHE41 Positively correlates with MDSC migration [30] YTHDF1 Reader EZH2 Positively correlates with MDSC recruitment and activation [31] γδ T cell METTL3 Writer STAT1 Positively correlates with equilibrate γδ T1 and γδ T17 cells [34] ALKBH5 Eraser Jagged1/Notch2 Negatively correlates with proliferation and differentiation of γδ T cell precursors [33] Mast cell METTL3 Writer IL-13 Negatively correlates with inflammatory responses of mast cells [38]