m6A甲基化修饰调控肿瘤免疫的研究进展

周海霞, 张靖

Research progress of m6A methylation modification in regulating tumor immunity

ZHOU Haixia, ZHANG Jing

表2 m6A修饰对适应性免疫细胞的调控作用

Tab 2 Role of m6A modifications in adaptive immune cells

Immune cell m6A regulator Type Related factor Function Reference CD4+ T cell METTL3 Writer SOCS Positively correlates with proliferation and differentiation of T cells [42] ALKBH5 Eraser IFN-γ, CXCL2 Positively correlates with Th1 cell activation [43] Treg cell METTL3 Writer SOCS Positively correlates with sustaining Treg suppressive functions [45] METTL14 Writer RORγt Positively correlates with Tregs differentiation [44] CD8+ T cell METTL3 Writer circIGF2BP3 Negatively correlates with CD8+T cell responses and facilitates tumor immune [48] METTL14 Writer Ebi3 Negatively correlates with dysfunctional CD8+T cell levels in patients with colorectal cancer [46] YTHDF1/2 Reader unkown Positively correlates with tumor-infiltrating lymphocytes, including CD8+ T cells [47] FTO Eraser c-Jun, JunB, and C/EBPβ Positively correlates with glycolytic metabolism of tumor cells; negatively correlates with CD8+T cell responses [49] B cell METTL14 Writer Lax1, Tipe2 Positively correlates with B cell maturation [52] FTO Eraser HSF1 Positively correlates with tumor-promoting and pro-metastatic in multiple myeloma [53]