黏附性G蛋白偶联受体F1在胰腺导管腺癌中的表达及其促进癌症进展的机制研究

陈溯源, 木司塔巴·木台力甫, 李冬雪, 张志刚

Expression of adhesion G protein-coupled receptor F1 in pancreatic ductal adenocarcinoma and its mechanism of promoting cancer progression

CHEN Suyuan, Mutailifu Musitaba, LI Dongxue, ZHANG Zhigang

图3 ADGRF1 在PDAC组织和细胞中的表达 Note： A. Expression of ADGRF1 mRNA in PDAC tissues were higher compared to para-carcinoma tissues in GSE15471, GSE16515, GSE28735 and Renji cohort datasets. B. Detection of the mRNA expression of ADGRF1 in eight PDAC cells and hTERT-HPNE cells by qPCR. C. Detection of the protein expression of ADGRF1 in eight PDAC cells and hTERT-HPNE cells by Western blotting. D. IHC was used to detect the expression of ADGRF1 in PDAC tissues and adjacent tissues of PDAC patients. ①P=0.000, compared with the non-tumor group; ②P=0.000, compared with the hTERN-HPNE group.

Fig 3 Analysis of the expression a of ADGRF1 in PDAC tissues and cells