氧化纳米铈清除活性氧改善DSS诱导的小鼠结肠炎疾病活动度的研究

卢雨涵, 石亚红, 龙满美, 王子, 吴颖为

Effect of ceria nanoparticles on activity of DSS-induced colitis in mice by eliminating active oxygen species

LU Yuhan, SHI Yahong, LONG Manmei, WANG Zi, WU Yingwei

图4 CeNP-PEG对结肠炎小鼠肠道促炎细胞因子表达水平的影响 Note： A. Ifn-γ mRNA level. ①P=0.000, compared with the DSS group; ②P=0.000, compared with the DSS+CeNP-PEG group; ③P=0.000, compared with the Normal group. B. Il-1β mRNA level. ①P=0.000, compared with the DSS group; ②P=0.000, compared with the DSS+CeNP-PEG group; ③P=0.000, compared with the Normal group. C. Il-6 mRNA level. ①P=0.000, compared with the DSS group; ②P=0.000, compared with the DSS+CeNP-PEG group; ③P=0.000, compared with the Normal group. D. Tnf-α mRNA level. ①P=0.000, compared with the DSS group; ②P=0.000, compared with the DSS+CeNP-PEG group; ③P=0.000, compared with the Normal group.

Fig 4 Effect of CeNP-PEG on the expression of proinflammatory cytokines in the colonic tissues of colitis mice