甲状腺弥漫性大B细胞淋巴瘤临床病理特征、基因突变谱及预后分析

杜沚珊, 王玥, 石子旸, 施晴, 易红梅, 董磊, 王黎, 程澍, 许彭鹏, 赵维莅

Clinicopathologic characteristics, gene mutation profile and prognostic analysis of thyroid diffuse large B-cell lymphoma

DU Zhishan, WANG Yue, SHI Ziyang, SHI Qing, YI Hongmei, DONG Lei, WANG Li, CHENG Shu, XU Pengpeng, ZHAO Weili

表2 影响甲状腺DLBCL患者预后的单因素分析

Tab 2 Univariate analysis in patients with thyroid DLBCL

Item PFS OS HR (95%CI) P value HR (95%CI) P value Gender 1.593 (0.558‒4.544) 0.380 1.638 (0.330‒8.117) 0.542 Age>60 years 1.699 (0.565‒5.113) 0.340 5.647 (0.635‒50.183) 0.084 ECOG score≥2 score 2.932 (0.640‒13.426) 0.146 2.940 (0.343‒25.216) 0.302 Ann Arbor stage Ⅲ‒Ⅳ 4.411 (1.373‒14.170) 0.007 7.088 (0.827‒60.717) 0.037 LDH elevated 5.500 (1.519‒19.911) 0.004 6.982 (0.809‒60.266) 0.040 Extranodal involvement≥2 2.505 (0.867‒7.235) 0.079 3.248 (0.593‒17.788) 0.151 non-GCB 5.291 (1.667‒16.788) 0.002 3.066 (0.597‒15.744) 0.159 DE 6.178 (1.813‒21.058) 0.001 18.079 (1.837‒177.923) 0.001 Thyroidectomy 0.259 (0.058‒1.162) 0.058 0.377 (0.044‒3.226) 0.354