超重肥胖青少年认知功能的改变及其与血清FGF21水平的关系
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韩瑞, 吴倩, 刘丹, 程棣, 张盈, 倪嘉成, 康飘, 陈安然, 于淑洁, 方启晨, 李华婷
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Alteration of cognitive function in overweight and obese adolescents and its relationship with serum FGF21 levels
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HAN Rui, WU Qian, LIU Dan, CHENG Di, ZHANG Ying, NI Jiacheng, KANG Piao, CHEN Anran, YU Shujie, FANG Qichen, LI Huating
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表1 3组受试者一般资料和实验室检测指标比较
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Tab 1 Comparison of general information and laboratory testing indicators among the three groups of subjects
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| Item | Normal weight group (n=50) | Overweight group (n=50) | Obese group (n=75) | P value |
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| General information | | | | | | Age/year | 15.18 ± 0.48 | 15.52 ± 0.58 | 15.31 ± 0.52 | 0.327 | | Gender (male/female)/n | 29/21 | 30/20 | 50/25 | 0.117 | | BMI/(kg·m-2) | 21.35 ± 2.16 | 25.26 ± 0.98* | 30.37 ± 2.73*# | 0.000 | | Body fat mass/kg | 12.73 ± 4.90 | 20.91 ± 4.69* | 29.95 ± 6.62*# | 0.000 | | Body fat percentage/% | 20.93 ± 7.73 | 28.47 ± 7.21* | 33.55 ± 5.83*# | 0.000 | | Waist circumference/cm | 73.95 ± 7.48 | 82.87 ± 3.69* | 95.53 ± 9.14*# | 0.000 | | Hip circumference/cm | 94.70 ± 5.77 | 103.71 ± 3.80* | 110.09 ± 5.38*# | 0.000 | | Waist-to-hip ratio | 0.80 ± 0.04 | 0.84 ± 0.01* | 0.89 ± 0.03*# | 0.000 | | SBP/mmHg | 115.04 ± 12.27 | 120.29 ± 11.51 | 124.39 ± 9.98* | 0.000 | | DBP/mmHg | 63.84 ± 7.42 | 69.09 ± 8.73* | 70.44 ± 9.27* | 0.000 | | Laboratory testing indicator | | | | | | FPG/(mmol·L-1) | 4.62 ± 0.35 | 4.78 ± 0.30 | 4.79 ± 0.37* | 0.014 | | FINS/(mmol·L-1) | 15.03 (11.43, 19.28) | 21.67 (17.62, 29.76)* | 29.94 (18.96, 38.32)*# | 0.000 | | HbA1c/% | 5.31 ± 0.21 | 5.32 ± 0.16 | 5.42 ± 0.27* | 0.008 | | Scr/(µmol·L-1) | 65.95 (58.40, 76.85) | 66.25 (56.33, 73.83)* | 71.90 (63.50, 79.50)* # | 0.052 | | UA/(µmol·L-1) | 368.86 ± 85.19 | 397.66 ± 82.31 | 451.24 ± 102.53* | 0.000 | | ALT/(U·L-1) | 14.00 (11.00, 17.25) | 17.50 (15.00, 27.00)* | 26.00 (20.00, 48.00)*# | 0.000 | | AST/(U·L-1) | 21.00 (17.75, 24.00) | 21.00 (18.00, 26.25) | 26.00 (20.00, 32.00)* | 0.000 | | GGT/(U·L-1) | 16.50 (14.00, 21.00) | 19.50 (14.75, 25.00) | 23.00 (17.00, 32.00)*# | 0.000 | | TC/(mmol·L-1) | 4.36 ± 0.78 | 4.30 ± 0.76* | 4.33 ± 0.74*# | 0.880 | | TAG/(mmol·L-1) | 0.74 (0.55, 1.04) | 0.87 (0.61, 1.29) | 0.92 (0.69, 1.37) | 0.012 | | HDL-Ch/(mmol·L-1) | 1.44 ± 0.29 | 1.26 ± 0.26* | 1.21 ± 0.25* | 0.000 | | LDL-Ch/(mmol·L-1) | 2.48 ± 0.70 | 2.56 ± 0.56 | 2.69 ± 0.69 | 0.076 |
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