癌-睾丸抗原CT63在慢性髓系白血病中的作用及其机制

孔汝心, 周亚群, 魏婷宜, 雷鸣

Function and mechanism of cancer-testis antigen CT63 in chronic myeloid leukemia

KONG Ruxin, ZHOU Yaqun, WEI Tingyi, LEI Ming

图3 CT63下调后K562细胞分化能力变化 Note： A/B. CT63 knockdown efficiency in K562 in RNA and protein level. C. Heat maps and hierarchical clustering of differently expressed mRNA in shCtrl and shCT63 K562 cells. D. GO function analysis of differently expressed mRNA in shCtrl and shCT63 K562 cells. E. qRT-PCR analysis of the expression of myeloid cell differentiation genes. ①P=0.000, ②P=0.000, ③P=0.063, ④P=0.001, ⑤P=0.000, ⑥P=0.000, ⑦P=0.001, ⑧P=0.077, ⑨P=0.001, ⑩P=0.003, compared with the shCtrl group.

Fig 3 Differentiation of K562 cells after CT63 downregulation