双同源盒诱导小鼠胚胎干细胞向胚外内胚层分化的机制研究

洪磊, 郭传亮, 蔡勤, 李婉睿, 曾溢滔, 薛燕, 曾凡一

Mechanism of DUX-induced differentiation of mESC into extraembryonic endoderm

HONG Lei, GUO Chuanliang, CAI Qin, LI Wanrui, ZENG Yitao, XUE Yan, ZENG Fanyi

图3 DUX过表达ESC的功能富集分析 Note： A. GO analysis of upregulated genes in plusDox ES cells. B. GSEA analysis showing collective changes in the retinol metabolism signaling pathway gene set. C. Expression levels (log2FC) (FC, fold change) of selected RA-pathway-related genes in plusDox and noDox cells (ESCs) based on RNA-seq data. D. Comparison of enrichment results from multiple gene lists.

Fig 3 Functional enrichment analysis of DUX overexpressed ESCs