黏蛋白1调控肿瘤细胞恶性特征的功能位点分析

高珂星, 廖春华, 李昇泽, 马双羽, 黄雷

Functional site analysis of mucin 1 in regulating the malignant characteristics of tumor cells

GAO Kexing, LIAO Chunhua, LI Shengze, MA Shuangyu, HUANG Lei

图4 MUC1-WT及其突变体对细胞增殖能力的影响 Note： A/B. Growth curves of BT549 cells (A) and MCF-10A cells (B) expressing MUC1-WT or mutants detected by CCK-8. C/D. Colony formation analysis of BT549 cells expressing MUC1-WT or mutants. Representative crystal violet-stained images (C) and corresponding statistical analysis (D). E/F. Colony formation analysis of MCF-10A cells expressing MUC1-WT or mutants. Representative crystal violet-stained images (E) and corresponding statistical analysis (F). ①P<0.001, ②P=0.003, ③P=0.005, ④P=0.007, ⑤P=0.009.

Fig 4 Effect of MUC1-WT and mutants on cell proliferation