黏蛋白1调控肿瘤细胞恶性特征的功能位点分析

高珂星, 廖春华, 李昇泽, 马双羽, 黄雷

Functional site analysis of mucin 1 in regulating the malignant characteristics of tumor cells

GAO Kexing, LIAO Chunhua, LI Shengze, MA Shuangyu, HUANG Lei

图6 MUC1-WT及其突变体对细胞干性的影响 Note： A/B. Sphere formation assay of BT549 cells expressing MUC1-WT or mutants. Representative images of spheres (A, ×100) and corresponding statistical analysis (B). C/D. Sphere formation assay of MCF-10A cells expressing MUC1-WT or mutants. Representative images of spheres (C, ×200) and corresponding statistical analysis (D). ①P<0.001, ②P=0.004, ③P=0.007, ④P=0.002.

Fig 6 Effect of MUC1-WT and mutants on cell stemness