黏蛋白1调控肿瘤细胞恶性特征的功能位点分析

高珂星, 廖春华, 李昇泽, 马双羽, 黄雷

Functional site analysis of mucin 1 in regulating the malignant characteristics of tumor cells

GAO Kexing, LIAO Chunhua, LI Shengze, MA Shuangyu, HUANG Lei

图7 SEA区域及附近的MUC1突变定位及相应突变体与EGFR-ECD的分子对接分析 Note： A. PyMoL software was used to localize MUC1 mutants in or around the SEA domain. B?E. ZDOCK Server was used to analyze the molecular docking of MUC1-WT (B) and mutants (C, S251R; D, N271S; E, V359I) with EGFR-ECD. Green represents the MUC1-N region (before the GSVVV sequence), orange represents the MUC1-C region (after the GSVVV sequence), blue represents EGFR-ECD region, and yellow represents the localization of the mutation sites.

Fig 7 Analysis of localization of MUC1 mutation sites in or around the SEA domain and molecular docking of the mutants with EGFR-ECD