纳米塑料诱导肺泡Ⅱ型上皮细胞DNA损伤加重重症哮喘

施泽纶, 王青, 何雯, 傅唯佳, 王颖雯, 韩晓, 张晓波

Nanoplastics aggravate severe asthma by inducing DNA damage of alveolar type Ⅱ epithelial cells

SHI Zelun, WANG Qing, HE Wen, FU Weijia, WANG Yingwen, HAN Xiao, ZHANG Xiaobo

图1 BALF炎症细胞计数、肺组织病理切片及组织病理学评分结果 Note： A. The flow cytometry results of the inflammatory cell counts (eosinophils, lymphocytes, macrophages and neutrophils) in the BALF of mice in each group. B. Pathological sections of mouse lung tissue: H-E staining (×200), PAS staining (×400), Ly6G immunohistochemical staining (×400). C. Eosinophil and airway inflammation scores. ①P<0.001, ④P=0.010, compared with the control group; ②P<0.001, ③P=0.025, ⑤P=0.005, ⑥P=0.023, compared with the HDM/PBS/PBS group.

Fig 1 Results of BALF inflammatory cell counts, lung tissue pathological sections and histopathological scores