纳米塑料诱导肺泡Ⅱ型上皮细胞DNA损伤加重重症哮喘

施泽纶, 王青, 何雯, 傅唯佳, 王颖雯, 韩晓, 张晓波

Nanoplastics aggravate severe asthma by inducing DNA damage of alveolar type Ⅱ epithelial cells

SHI Zelun, WANG Qing, HE Wen, FU Weijia, WANG Yingwen, HAN Xiao, ZHANG Xiaobo

图2 暴露于PS-NPs对重症哮喘小鼠BALF炎症细胞计数、肺组织病理切片及组织病理学评分结果的影响 Note： A. The flow cytometry results of the inflammatory cell (eosinophils, lymphocytes, macrophages and neutrophils) counts in the BALF of mice in each group after exposure to PS-NPs. B. Pathological sections of mouse lung tissue, including H-E staining (×200), PAS staining (×400), Ly6G immunohistochemical staining (×400). C. Eosinophil and airway inflammation scores. ①P<0.001, ④P=0.035, ⑤P=0.002, compared with the control group; ②P<0.001, ③P=0.001, ⑥P=0.008, ⑦P=0.002, compared with the HDM/LPS/PBS group.

Fig 2 Effect of exposure to PS-NPs on BALF inflammatory cell counts, lung tissue pathological sections and histopathological scores in mice with severe asthma