纳米塑料诱导肺泡Ⅱ型上皮细胞DNA损伤加重重症哮喘

施泽纶, 王青, 何雯, 傅唯佳, 王颖雯, 韩晓, 张晓波

Nanoplastics aggravate severe asthma by inducing DNA damage of alveolar type Ⅱ epithelial cells

SHI Zelun, WANG Qing, HE Wen, FU Weijia, WANG Yingwen, HAN Xiao, ZHANG Xiaobo

图7 体内实验证实PS-NPs暴露上调重症哮喘小鼠 Sftpc＋AT2中ATR、p53表达水平 Note： A. AT2 cells from lung tissues were co-stained with ATR (red) and SFTPC (green) and DAPI (blue) (×400, ×800). B. AT2 cells from lung tissues were co-stained with p53 (red) and SFTPC (green) and DAPI (blue) (×400, ×800).

Fig 7 In vivo experiments confirmed that the upregulated expression levels of ATR and p53 in Sftpc＋ AT2 cells of severe asthma mice after PS-NPs exposure